Introduction：Basic information about CAS 171714-84-4|Darusentan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Darusentan |
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| CAS Number | 171714-84-4 | Molecular Weight | 410.420 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 587.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H22N2O6 | Melting Point | / |
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| MSDS | / | Flash Point | 309.0±32.9 °C |
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Names
| Name | (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid |
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| Synonym | More Synonyms |
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Darusentan BiologicalActivity
| Description | Darusentan is a selective endothelin A (ETA) receptor antagonist. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki=13 nM[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Endothelin Receptor |
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| References | [1]. Liang F, et al. Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries. Can J Physiol Pharmacol. 2010 Aug;88(8):840-9. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 587.3±60.0 °C at 760 mmHg |
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| Molecular Formula | C22H22N2O6 |
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| Molecular Weight | 410.420 |
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| Flash Point | 309.0±32.9 °C |
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| Exact Mass | 410.147797 |
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| PSA | 100.00000 |
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| LogP | 6.90 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| InChIKey | FEJVSJIALLTFRP-LJQANCHMSA-N |
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| SMILES | COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 |
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Safety Information
Synonyms
| Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)- |
| (+)-(S)-2-(4,6-dimethoxypyrimidine-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid |
| (2S)-2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid |
| HMR-4005 |
| henyl-,(S) |
| Darusentan |
| (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid |
| (2S)-2-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid |
