CAS 5611-51-8|Triamcinolone hexacetonide
Introduction：Basic information about CAS 5611-51-8|Triamcinolone hexacetonide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Triamcinolone hexacetonide | ||
|---|---|---|---|
| CAS Number | 5611-51-8 | Molecular Weight | 532.64100 |
| Density | 1.24 g/cm3 | Boiling Point | 619.5ºC |
| Molecular Formula | C30H41FO7 | Melting Point | / |
| MSDS | / | Flash Point | 328.5ºC |
Names
| Name | triamcinolone hexacetonide |
|---|---|
| Synonym | More Synonyms |
Triamcinolone hexacetonide BiologicalActivity
| Description | Triamcinolone hexacetonide is a commonly used long-acting steroids in treatment of subacute and chronic inflammatory joint diseases. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vivo | Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation[1]. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure[2]. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration[3]. |
| Animal Admin | Guinea pigs: Animals are given intraarticular injection of 0.1 mL of Triamcinolone hexacetonide provided a dose of 0.40 mg/kg (groups 2 and 3) or 0.04 mg/kg (groups 4 and 5). The volume of CMC injected into the knees of group 6 animals is the same as that used for the intraarticular injections in the other groups, i.e., 0.1 mL. When the animals are killed, both knees are immediately opened and examined grossly[1]. |
| References | [1]. Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74. [2]. Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205. [3]. Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9. |
Chemical & Physical Properties
| Density | 1.24 g/cm3 |
|---|---|
| Boiling Point | 619.5ºC |
| Molecular Formula | C30H41FO7 |
| Molecular Weight | 532.64100 |
| Flash Point | 328.5ºC |
| Exact Mass | 532.28400 |
| PSA | 99.13000 |
| LogP | 4.40590 |
| Index of Refraction | 1.556 |
| InChIKey | TZIZWYVVGLXXFV-FLRHRWPCSA-N |
| SMILES | CC(C)(C)CC(=O)OCC(=O)C12OC(C)(C)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 10-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 10-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- 46IEAC "Current Research Trends in Prenatal Craniofacial Development, Proceedings of an International Conference, 1980," Pratt, R.M., and R.L. Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980 Volume(issue)/page/year: -,387,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919- Volume(issue)/page/year: 58(Spec Iss A),384,197
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1974- Volume(issue)/page/year: 13,443,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5557 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1088 (estimated) No. of Female Employees: 744 (estimated)
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles28
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| Effectiveness of intra-articular injection in wrist joints according to triamcinolone hexacetonide dose in rheumatoid arthritis: a randomized controlled double-blind study. Am. J. Phys. Med. Rehabil. 94(2) , 131-8, (2015) The aim of this study was to compare the effectiveness in the medium term between low and high doses of triamcinolone hexacetonide used in intra-articular injection in medium-sized joints of rheumatoi... | |
| Does modern treatment of early rheumatoid arthritis reduce the need for intra-articular glucocorticoids? Scand. J. Rheumatol. 42(2) , 163-4, (2013) |
Synonyms
| Aristospan (TN) |
| Tiamcinoloni hexacetonidum [INN] |
| EINECS 227-031-4 |
| UNII-I7GT1U99Y9 |
| TATBA |
| Lederspan |
| Triamcinolone esacetonide [DCIT] |
