Introduction：Basic information about CAS 86030-08-2|BTB1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BTB1 |
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| CAS Number | 86030-08-2 | Molecular Weight | 297.71400 |
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| Density | 1.476g/cm3 | Boiling Point | 471.2ºC at 760mmHg |
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| Molecular Formula | C12H8ClNO4S | Melting Point | 115ºC |
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| MSDS | / | Flash Point | 238.8ºC |
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Names
| Name | 1-(benzenesulfonyl)-4-chloro-2-nitrobenzene |
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| Synonym | More Synonyms |
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BTB1 BiologicalActivity
| Description | BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/TubulinResearch Areas >>Cancer |
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| Target | IC50: 1.69 μM (Kif18A)[1] |
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| In Vitro | BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner[1]. BTB-1 shows cell toxicity with an EC50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles[2]. |
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| Kinase Assay | BTB-1 is prepared in DMSO. The activity of His-Kif18Amotor at increasing concentrations of ATP is monitored in the presence of 3 μM Mts and increasing concentrations of BTB-1 (0.21 μM, 0.42 μM, 0.85 μM, 1.7 μM) or DMSO as control[1]. |
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| References | [1]. Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6. [2]. Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60. |
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Chemical & Physical Properties
| Density | 1.476g/cm3 |
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| Boiling Point | 471.2ºC at 760mmHg |
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| Melting Point | 115ºC |
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| Molecular Formula | C12H8ClNO4S |
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| Molecular Weight | 297.71400 |
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| Flash Point | 238.8ºC |
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| Exact Mass | 296.98600 |
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| PSA | 88.34000 |
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| LogP | 4.68500 |
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| Index of Refraction | 1.623 |
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| InChIKey | VZDUQPHKUBZMLW-UHFFFAOYSA-N |
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| SMILES | O=[N+]([O-])c1cc(Cl)ccc1S(=O)(=O)c1ccccc1 |
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| Storage condition | 2-8℃ |
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Safety Information
| Risk Phrases | 36/37/38 |
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| Safety Phrases | S26-S36-S37-S39 |
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Synonyms
| 4-Chloro-2-nitrodiphenylsulfone |
| 4-Chlor-2-nitro-diphenylsulfon |
| 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene |
| (4-Chlor-2-nitro-phenyl)-phenyl-sulfon |
| 4-chloro-2-nitrodiphenyl sulphone |
| 4-chloro-2-nitrophenyl phenyl sulfone |
| BTB-1 |
