CAS 88-14-2|Furan-2-carboxylic acid
Introduction：Basic information about CAS 88-14-2|Furan-2-carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Furan-2-carboxylic acid | ||
|---|---|---|---|
| CAS Number | 88-14-2 | Molecular Weight | 112.084 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 230-232 ºC |
| Molecular Formula | C5H4O3 | Melting Point | 129-133 ºC |
| MSDS | ChineseUSA | Flash Point | 137 ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-furoic acid |
|---|---|
| Synonym | More Synonyms |
Furan-2-carboxylic acid BiologicalActivity
| Description | 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[1]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseSignaling Pathways >>Metabolic Enzyme/Protease >>ATP Citrate LyaseResearch Areas >>Metabolic Disease |
| In Vivo | 2-Furoic acid significantly reduces serum cholesterol and serum triglyceride levels[2]. 2-Furoic acid also lowers the liver and small intestine ATP dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase and heparin induced lipoprotein lipase activities[2]. 2-Furoic acid shows the LD50 of 250 mg/kg i.p. in the acute toxicity studies in mice[2]. |
| References | [1]. Wordofa GG, et al. Tolerance and metabolic response of Pseudomonas taiwanensis VLB120 towards biomass hydrolysate-derived inhibitors. Biotechnol Biofuels. 2018 Jul 19;11:199. [2]. Hall IH, et al. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 230-232 ºC |
| Melting Point | 129-133 ºC |
| Molecular Formula | C5H4O3 |
| Molecular Weight | 112.084 |
| Flash Point | 137 ºC |
| Exact Mass | 112.016045 |
| PSA | 50.44000 |
| LogP | 0.64 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.513 |
| InChIKey | SMNDYUVBFMFKNZ-UHFFFAOYSA-N |
| SMILES | O=C(O)c1ccco1 |
| Water Solubility | 36 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 10 ug/plate
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1977 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 774 (estimated) No. of Female Employees: 10 (estimated)
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 10 ug/plate
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1977 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 774 (estimated) No. of Female Employees: 10 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | C;Xi |
| Risk Phrases | R34;R36/37/38 |
| Safety Phrases | S26-S36/37/39-S45-S36 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LV1763000 |
| HS Code | 29321900 |
Customs
| HS Code | 2932190090 |
|---|---|
| Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
Articles38
More Articles| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days... | |
| Optimization and Kinetic Studies on Biodiesel Production from Kusum (Schleichera triguga) Oil Using Response Surface Methodology. J. Oleo Sci. 64 , 987-97, (2015) In the present study, the low-cost non-edible kusum (Schleichera triguga) oil with a substantial amount of free fatty acid (FFA) was utilized for biodiesel synthesis. In pretreatment step, FFA was red... | |
| High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue. Biotechnol. Bioeng. 112 , 1770-82, (2015) Corncob residue as the lignocellulosic biomass accumulated phenolic compounds generated from xylitol production industry. For utilization of this biomass, Zymomonas mobilis ZM4 was tested as the ethan... |
Synonyms
| 2-furanyl-carboxylic acid |
| pyromucic acid |
| Furan-2-carboxylic acid |
| 2-FURANCARBONYL CHLORIDE |
| 2-Furoic acid |
| a-Furoicacid |
| Kyselina 2-furoova |
| 2- FUROIC ACID |
| 2-FUROIC ACID/FURAN-2-CARBOXYLIC ACID |
| Furoica |
| 2-FURANCARBOXYLICACID |
| α-Furoic acid |
| EINECS 208-422-9 |
| 2-Furanoic acid |
| 2-Furancarboxylic acid |
| MFCD00003228 |
| 2-furan-carboxylic acid |
| a-Furoic Acid |
