CAS 10041-06-2|Ro 22-3581
| Common Name | Ro 22-3581 | ||
|---|---|---|---|
| CAS Number | 10041-06-2 | Molecular Weight | 186.21000 |
| Density | 1.13g/cm3 | Boiling Point | 360.9ºC at 760 mmHg |
| Molecular Formula | C11H10N2O | Melting Point | 108-110 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 172.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4'-(imidazol-1-yl)acetophenone |
|---|---|
| Synonym | More Synonyms |
Ro 22-3581 BiologicalActivity
| Description | Ro 22-3581 (4'-(Imidazol-1-yl) acetophenone) is a selective thromboxane (Tx) synthetase inhibitor[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| Target | Thromboxane synthetase[1] |
| References | [1]. Uderman HD, et al. Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. Prostaglandins. 1982 Aug;24(2):237-44. |
Chemical & Physical Properties
| Density | 1.13g/cm3 |
|---|---|
| Boiling Point | 360.9ºC at 760 mmHg |
| Melting Point | 108-110 °C(lit.) |
| Molecular Formula | C11H10N2O |
| Molecular Weight | 186.21000 |
| Flash Point | 172.1ºC |
| Exact Mass | 186.07900 |
| PSA | 34.89000 |
| LogP | 2.07490 |
| Vapour Pressure | 2.15E-05mmHg at 25°C |
| Index of Refraction | 1.593 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles5
More Articles| Suppression of urinary albumin excretion in diabetic rats by 4'(imidazol-1-yl) acetophenone, a selective inhibitor of thromboxane synthesis. J. Lab. Clin. Med. 116(4) , 469-78, (1990) Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we... | |
| Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. Prostaglandins 23(3) , 273-85, (1982) We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in p... | |
| Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. Prostaglandins 24(2) , 237-44, (1982) The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted ... |
Synonyms
| 4’-(1-Imidazolyl)acetophenone |
| 1-(4-(1H-Imidazol-1-yl)phenyl)ethanone |
| MFCD00005282 |
| 1-(4-imidazol-1-ylphenyl)ethanone |
| 4‘-(Imidazol-1-yl)acetophenone |
| EINECS 233-123-5 |
