CAS 672-87-7|Metyrosine
| Common Name | Metyrosine | ||
|---|---|---|---|
| CAS Number | 672-87-7 | Molecular Weight | 195.21500 |
| Density | 1.283g/cm3 | Boiling Point | 383.7ºC at 760 mmHg |
| Molecular Formula | C10H13NO3 | Melting Point | 320-340°C dec. |
| MSDS | ChineseUSA | Flash Point | 185.9ºC |
Names
| Name | α-methyl-L-tyrosine |
|---|---|
| Synonym | More Synonyms |
Metyrosine BiologicalActivity
| Description | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>COX |
| In Vitro | Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2]. |
| In Vivo | Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1]. Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2] Dosage: 50, 100 or 200 mg/kg Administration: I.p. Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h). |
| References | [1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. |
Chemical & Physical Properties
| Density | 1.283g/cm3 |
|---|---|
| Boiling Point | 383.7ºC at 760 mmHg |
| Melting Point | 320-340°C dec. |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.21500 |
| Flash Point | 185.9ºC |
| Exact Mass | 195.09000 |
| PSA | 83.55000 |
| LogP | 1.43700 |
| Index of Refraction | 1.599 |
| InChIKey | NHTGHBARYWONDQ-JTQLQIEISA-N |
| SMILES | CC(N)(Cc1ccc(O)cc1)C(=O)O |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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| Effects of intratumoral inflammatory process on 18F-FDG uptake: pathologic and comparative study with 18F-fluoro-α-methyltyrosine PET/CT in oral squamous cell carcinoma. J. Nucl. Med. 56(1) , 16-21, (2015) The accurate depiction of both biologic and anatomic profiles of tumors has long been a challenge in PET imaging. An inflammation, which is innate in the carcinogenesis of oral squamous cell carcinoma... |
Synonyms
| MFCD00064201 |
| (S)-alpha-Methyltyrosine |
| α-METHYL-L-P-TYROSINE |
| alpha-methyl-L-tyrosine |
| EINECS 211-599-5 |
