CAS 81938-43-4|Zofenopril calcium
| Common Name | Zofenopril calcium | ||
|---|---|---|---|
| CAS Number | 81938-43-4 | Molecular Weight | 448.58 |
| Density | 1.34 g/cm3 | Boiling Point | 646.3ºC at 760 mmHg |
| Molecular Formula | C22H22Ca0.5NO4S2 | Melting Point | >250ºC |
| MSDS | ChineseUSA | Flash Point | 344.7ºC |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | zofenopril calcium |
|---|---|
| Synonym | More Synonyms |
Zofenopril calcium BiologicalActivity
| Description | Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.Target: ACEZofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1]. Zofenopril promotes the regeneration of peripheral nerve injuries in rat models [2]. Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR [3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Cardiovascular Disease |
| References | [1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94. [2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6. [3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63. |
Chemical & Physical Properties
| Density | 1.34 g/cm3 |
|---|---|
| Boiling Point | 646.3ºC at 760 mmHg |
| Melting Point | >250ºC |
| Molecular Formula | C22H22Ca0.5NO4S2 |
| Molecular Weight | 448.58 |
| Flash Point | 344.7ºC |
| PSA | 228.56000 |
| LogP | 7.80660 |
| InChIKey | NSYUKKYYVFVMST-LETVYOFWSA-L |
| SMILES | CC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].CC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].[Ca+2] |
| Storage condition | Refrigerator |
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | N |
| Risk Phrases | 50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
Articles25
More Articles| Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions. Cardiovasc. Ther. 27(4) , 275-88, (2009) Zofenopril, is a highly lipophilic ACE inhibitor, characterized by long-lasting tissue penetration and sustained cardiac ACE inhibition, indicated for the treatment of hypertension and myocardial infa... | |
| Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma. J. Pharm. Biomed. Anal. 55(3) , 527-32, (2011) A novel, sensitive and rapid liquid chromatographic-electrospray ionization mass spectrometric method was developed and validated for the determination of zofenopril and its active metabolite zofenopr... | |
| Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits. J. Cardiovasc. Pharmacol. Ther. 15(4) , 384-92, (2010) Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inh... |
Synonyms
| Calcium bis[(2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-2-pyrrolidinecarboxylate] |
| ZOFENOPRIL CALCIUM |
| Calcium bis[(2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylate] |
| L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, (4S)- (2:1) |
| MFCD08704648 |
| Zofenopril calcium salt |
