CAS 1071-37-0|Ethyl carbamimidothioate hydrobromide (1:1)
Introduction：Basic information about CAS 1071-37-0|Ethyl carbamimidothioate hydrobromide (1:1), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Research Areas >>Others
In Vitro
EIT (S-ethylisothiourea) Hydrobromide 是 II 型 NOS 的选择性抑制剂。EIT 对 LPS 诱导的血浆 [NOx] 增加产生剂量依赖性和 > 95% 的抑制。EIT 的 ED50 值为 0.4 mg/kg。用 L-精氨酸（但不是 D-精氨酸）预处理可防止死亡率，同时不影响 II 型 NOS 依赖性 NO 的产生，表明毒性可能是由于抑制其他 NOS 亚型（内皮或神经元）之一 [1 ].选择性 NOS II 拮抗剂减弱但不阻断胎儿肺中剪切应力诱导的血管舒张。NOS II 活性的刺激（可能来自平滑肌细胞）在剪切应力诱导的肺血管舒张过程中部分促成了 NO 介导的 PVR（肺血管阻力）下降。在存在 AMT 或另一种选择性 iNOS 抑制剂 S-乙基异硫脲 (EIT) 的情况下用同种异体抗原刺激的脾细胞比在没有 iNOS 抑制剂的情况下刺激的细胞产生更多的白细胞介素 (IL)-4 和 IL-10。Th1 细胞因子 IL-2 和干扰素 (IFN)-γ 的产生并未因抑制 NO 合成而增强 。急性给予 EIT (380 nmol/h)，另一种诱导型一氧化氮合酶选择性抑制剂，也减弱了妊娠引起的肾小球滤过率和有效肾血浆流量的增加。
Chemical & Physical Properties
Density
1.19 g/cm3
Boiling Point
159.6ºC at 760 mmHg
Melting Point
79-81°C
Molecular Formula
C3H9BrN2S
Molecular Weight
185.09
Flash Point
50.3ºC
Exact Mass
183.966980
PSA
75.17000
LogP
2.39110
Vapour Pressure
2.26mmHg at 25°C
Index of Refraction
1.548
InChIKey
SWXXKWPYNMZFTE-UHFFFAOYSA-N
SMILES
Br.CCSC(=N)N
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
UM6825000
CHEMICAL NAME :
Pseudourea, 2-ethyl-2-thio-, hydrobromide
CAS REGISTRY NUMBER :
1071-37-0
LAST UPDATED :
198706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C3-H8-N2-S.Br-H
MOLECULAR WEIGHT :
185.11
WISWESSER LINE NOTATION :
SHYZUN2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974
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