CAS 100202-39-9|Methyl azetidine-3-carboxylate hydrochloride

Introduction：Basic information about CAS 100202-39-9|Methyl azetidine-3-carboxylate hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMethyl azetidine-3-carboxylate hydrochloride
CAS Number100202-39-9Molecular Weight151.591
Density/Boiling Point190.9ºC at 760 mmHg
Molecular FormulaC5H10ClNO2Melting Point93.0 to 97.0 °C
MSDSUSAFlash Point69.3ºC

Names

NameMethyl azetidine-3-carboxylate hydrochloride
SynonymMore Synonyms

BiologicalActivity

DescriptionMethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
Related CatalogResearch Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Non-cleavable

In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Boiling Point190.9ºC at 760 mmHg
Melting Point93.0 to 97.0 °C
Molecular FormulaC5H10ClNO2
Molecular Weight151.591
Flash Point69.3ºC
Exact Mass151.040009
PSA38.33000
LogP0.50960
InChIKeyUOCWTLBPYROHEF-UHFFFAOYSA-N
SMILESCOC(=O)C1CNC1.Cl

Safety Information

Hazard CodesXi
Risk Phrases36
Safety Phrases26
HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Azetidine-3-carboxylic Acid Methyl Ester Hydrochloride
3-Azetidinecarboxylic acid, methyl ester, hydrochloride (1:1)
Methyl 3-azetidinecarboxylate hydrochloride (1:1)
Methyl Azetidine-3-carboxylate Hydrochloride
Methyl 3-azetidinecarboxylate hydrochloride
Methyl azetidine-3-carboxylate hydrochloride (1:1)
methyl azetidine-3-carboxylate,hydrochloride
methylazetidine-3-carboxylatehydrochloride
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