CAS 17692-51-2|Metergoline

Introduction：Basic information about CAS 17692-51-2|Metergoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Metergoline BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles30
7. Synonyms

Common Name	Metergoline
CAS Number	17692-51-2	Molecular Weight	403.51700
Density	1.25g/cm3	Boiling Point	612.5ºC at 760mmHg
Molecular Formula	C₂₅H₂₉N₃O₂	Melting Point	148-150 °C(lit.)
MSDS	ChineseUSA	Flash Point	324.2ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	metergoline
Synonym	More Synonyms

Metergoline BiologicalActivity

Description	Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Neurological Disease

Chemical & Physical Properties

Density	1.25g/cm3
Boiling Point	612.5ºC at 760mmHg
Melting Point	148-150 °C(lit.)
Molecular Formula	C₂₅H₂₉N₃O₂
Molecular Weight	403.51700
Flash Point	324.2ºC
Exact Mass	403.22600
PSA	46.50000
LogP	4.39350
Vapour Pressure	0mmHg at 25°C
InChIKey	WZHJKEUHNJHDLS-QTGUNEKASA-N
SMILES	CN1CC(CNC(=O)OCc2ccccc2)CC2c3cccc4c3c(cn4C)CC21
Storage condition	−20°C
Water Solubility	0.1 M HCl: 1.4 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FA1070000

CHEMICAL NAME :: Carbamic acid, (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, benzyl ester

CAS REGISTRY NUMBER :: 17692-51-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C25-H29-N3-O2

MOLECULAR WEIGHT :: 403.57

WISWESSER LINE NOTATION :: T C6656 1A P GN LNTT&&J E1MVO1R& G1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4176182

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 ug/kg

SEX/DURATION :: lactating female 5 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum Reproductive - Maternal Effects - other effects

REFERENCE :: OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 51,113,1978

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	FA1070000

Articles30

5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.

Comp. Biochem. Physiol. B Biochem. Mol. Biol. 164(2) , 117-23, (2013)

The presence of distinct class of 5-HT receptors in the melanophores of tilapia (Oreochromis mossambicus) is reported. The cellular responses to 5-HT (5-hydroxytryptamine), 5-HT(1), and 5-HT(2), agoni...

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.

Elife 4 , (2015)

Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act dur...

Pharmacological characterisation of the thermogenic effect of bupropion.

Eur. J. Pharmacol. 498(1-3) , 219-25, (2004)

The pharmacological mechanism of bupropion's thermogenic effect has been investigated in female Wistar rats by measuring oxygen consumption at thermoneutrality (29 degrees C). Bupropion (30 mg/kg) rap...

Synonyms

Metergoline,[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester

EINECS 241-686-3

MFCD00153829

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