CAS 60563-36-2|DCEBIO
| Common Name | DCEBIO | ||
|---|---|---|---|
| CAS Number | 60563-36-2 | Molecular Weight | 231.08 |
| Density | 1.413g/cm3 | Boiling Point | / |
| Molecular Formula | C9H8Cl2N2O | Melting Point | 209.5-210.5 °C |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one |
|---|---|
| Synonym | More Synonyms |
DCEBIO BiologicalActivity
| Description | DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| Target | Cl－ secretion[1] |
| References | [1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64. [2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. |
Chemical & Physical Properties
| Density | 1.413g/cm3 |
|---|---|
| Melting Point | 209.5-210.5 °C |
| Molecular Formula | C9H8Cl2N2O |
| Molecular Weight | 231.08 |
| Exact Mass | 230.00100 |
| PSA | 37.79000 |
| LogP | 2.65630 |
| Index of Refraction | 1.592 |
| InChIKey | LKHRMULASXZCLG-UHFFFAOYSA-N |
| SMILES | CCn1c(=O)[nH]c2cc(Cl)c(Cl)cc21 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles2
More Articles| The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels in Human Glioma Cells. Cell Physiol. Biochem. 37 , 1390-406, (2015) Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels ... | |
| Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir. Res. 10 , 120, (2009) Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subse... |
Synonyms
| 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one |
| 5,6-dichloro-1-ethyl-1,3-dihydro-benzoimidazol-2-one |
| DC-EBIO |
| 5,6-dichloro-3-ethyl benzimidazolone |
| 5,6-Dichlor-1-ethyl-benzimidazolon |
| 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
| 5,6-dichloro-1-ethyl-benzimidazolinone |
| Tocris-1422 |
| 5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin |
| dichloro-EBIO |
