CAS 128312-51-6|Cinalukast
| Common Name | Cinalukast | ||
|---|---|---|---|
| CAS Number | 128312-51-6 | Molecular Weight | 412.54500 |
| Density | 1.258g/cm3 | Boiling Point | / |
| Molecular Formula | C23H28N2O3S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | cinalukast |
|---|---|
| Synonym | More Synonyms |
Cinalukast BiologicalActivity
| Description | Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Leukotriene ReceptorResearch Areas >>Inflammation/Immunology |
| Target | IC50: 6.4 nM (LTD4)[1] |
| In Vitro | Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1]. |
| In Vivo | Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1]. Animal Model: Guinea pigs[1] Dosage: 10 mg/kg Administration: Oral gavage; 10 mg/kg once Result: Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs. |
Chemical & Physical Properties
| Density | 1.258g/cm3 |
|---|---|
| Molecular Formula | C23H28N2O3S |
| Molecular Weight | 412.54500 |
| Exact Mass | 412.18200 |
| PSA | 107.53000 |
| LogP | 5.87360 |
| Index of Refraction | 1.655 |
| InChIKey | BZMKNPGKXJAIDV-VAWYXSNFSA-N |
| SMILES | CCC(CC)(CC(=O)Nc1cccc(C=Cc2nc(C3CCC3)cs2)c1)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles11
More Articles| Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death. J. Physiol. Pharmacol. 60(3) , 135-43, (2009) Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by in... | |
| Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast. J. Allergy Clin. Immunol. 99(2) , 210-5, (1997) The degree and duration of protection against exercise-induced bronchoconstriction afforded by three doses of a specific leukotriene D4 receptor antagonist, cinalukast, were assessed after an initial ... | |
| Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma. Biochem. Pharmacol. 44(7) , 1411-5, (1992) We have identified and characterized two different subclasses of binding site for the novel peptido-leukotriene (LT) antagonist, [3H]ICI 198,615, in membranes from human lung parenchyma using a recept... |
Synonyms
| Cinalukast |
| 4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid |
