CAS 504433-23-2|GW441756

Introduction：Basic information about CAS 504433-23-2|GW441756, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. GW441756 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	GW441756
CAS Number	504433-23-2	Molecular Weight	275.305
Density	1.3±0.1 g/cm3	Boiling Point	568.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₃N₃O	Melting Point	/
MSDS	/	Flash Point	297.3±30.1 °C

Names

Name	1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Synonym	More Synonyms

GW441756 BiologicalActivity

Description	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.IC50 Value: 2 nM [1]Target: TrkAin vitro: GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a during DNA damage by doxorubicin treatment, but not by GW441756 [2].
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Trk ReceptorResearch Areas >>Cancer
References	[1]. Wood ER, Kuyper L, Petrov KG, Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. [2]. Eun Joo Jung, Choong Won Kim, Deok Ryong Kim. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp Mol Med. 2008 June 30; 40(3): 276-285.

Description

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.IC50 Value: 2 nM [1]Target: TrkAin vitro: GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a during DNA damage by doxorubicin treatment, but not by GW441756 [2].

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Trk ReceptorResearch Areas >>Cancer

References

[1]. Wood ER, Kuyper L, Petrov KG, Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.

[2]. Eun Joo Jung, Choong Won Kim, Deok Ryong Kim. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp Mol Med. 2008 June 30; 40(3): 276-285.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	568.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₃N₃O
Molecular Weight	275.305
Flash Point	297.3±30.1 °C
Exact Mass	275.105865
PSA	46.92000
LogP	2.90
Appearance of Characters	light yellow solid
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.708
InChIKey	NXNQLECPAXXYTR-UHFFFAOYSA-N
SMILES	Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21
Storage condition	Store at RT

Synonyms

(3E)-3-[(1-Methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-, (3Z)-

(3Z)-3-[(1-Methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-, (3E)-

(3Z)-3-[(1-methyl-1H-indol-3-yl)methylidene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

GW 441756

GW441756

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