Introduction：Basic information about CAS 72420-38-3|Acifran, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acifran |
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| CAS Number | 72420-38-3 | Molecular Weight | 218.20500 |
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| Density | 1.343 g/cm3 | Boiling Point | 378.4ºC at 760 mmHg |
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| Molecular Formula | C12H10O4 | Melting Point | / |
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| MSDS | / | Flash Point | 149.4ºC |
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Names
| Name | 5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid |
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| Synonym | More Synonyms |
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Acifran BiologicalActivity
| Description | Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>GPR109A |
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| References | [1]. M N Cayen, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica. 1986 Mar;16(3):251-63. [2]. Jae-Kyu Jung, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8. |
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Chemical & Physical Properties
| Density | 1.343 g/cm3 |
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| Boiling Point | 378.4ºC at 760 mmHg |
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| Molecular Formula | C12H10O4 |
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| Molecular Weight | 218.20500 |
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| Flash Point | 149.4ºC |
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| Exact Mass | 218.05800 |
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| PSA | 63.60000 |
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| LogP | 1.46960 |
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| Index of Refraction | 1.591 |
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| InChIKey | DFDGRKNOFOJBAJ-UHFFFAOYSA-N |
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| SMILES | CC1(c2ccccc2)OC(C(=O)O)=CC1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LU0222000
- CHEMICAL NAME :
- 2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-
- CAS REGISTRY NUMBER :
- 72420-38-3
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C12-H10-O4
- MOLECULAR WEIGHT :
- 218.22
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,1154,1982
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Synonyms
