CAS 112924-45-5|Dexanabinol
Introduction：Basic information about CAS 112924-45-5|Dexanabinol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dexanabinol | ||
|---|---|---|---|
| CAS Number | 112924-45-5 | Molecular Weight | 386.567 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 470.1±45.0 °C at 760 mmHg |
| Molecular Formula | C25H38O3 | Melting Point | / |
| MSDS | / | Flash Point | 238.1±28.7 °C |
Names
| Name | (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol |
|---|---|
| Synonym | More Synonyms |
Dexanabinol BiologicalActivity
| Description | Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative and lacks cannabimimetic effects. Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death. Dexanabinol is widely used in head injury or stroke treatment and has been shown to be safe in animals and humans[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>Apoptosis >>TNF ReceptorResearch Areas >>Neurological Disease |
| Target | NF-κB TNFα IL-6 |
| References | [1]. He X, et al. Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine. 2016 Oct 3;11:4975-4990. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.1±45.0 °C at 760 mmHg |
| Molecular Formula | C25H38O3 |
| Molecular Weight | 386.567 |
| Flash Point | 238.1±28.7 °C |
| Exact Mass | 386.282104 |
| PSA | 49.69000 |
| LogP | 8.19 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.526 |
| InChIKey | SSQJFGMEZBFMNV-PMACEKPBSA-N |
| SMILES | CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)C1CC=C(CO)CC21 |
Synonyms
| 6H-Dibenzo[b,d]pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS,10aS)- |
| (6aS,10aS)-9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyl-2-octanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol |
| (6aS,10aS)-9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol |
| Sinnabidiol |
| 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol |
| HU-211 |
| Dexanabinol |
