Introduction：Basic information about CAS 31362-50-2|Bombesin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bombesin |
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| CAS Number | 31362-50-2 | Molecular Weight | 1619.85000 |
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| Density | 1.5g/cm3 | Boiling Point | / |
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| Molecular Formula | C71H110N24O18S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | Bombesin |
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| Synonym | More Synonyms |
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Bombesin BiologicalActivity
| Description | Bombesin is a tetradecapeptide originally isolated from frog skin; plays an important role in the release of gastrin and the activation of G-protein receptors. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Bombesin ReceptorResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseNatural Products >>OthersPeptides |
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| In Vitro | Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB)[1]. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus[2]. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC50=1 nM)[3]. |
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| References | [1]. Gonzalez N, et al. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):58-64. [2]. Chejfec G, et al. Bombesin in human neuroendocrine (NE) neoplasms. Peptides. 1985;6 Suppl 3:107-12. |
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Chemical & Physical Properties
| Density | 1.5g/cm3 |
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| Molecular Formula | C71H110N24O18S |
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| Molecular Weight | 1619.85000 |
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| Exact Mass | 1618.82000 |
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| PSA | 711.43000 |
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| LogP | 2.59880 |
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| Index of Refraction | 1.681 |
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| InChIKey | QXZBMSIDSOZZHK-DOPDSADYSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(C)C)C(N)=O |
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| Storage condition | −20°C |
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| Water Solubility | 0.05 M acetic acid: 20 mg/mL, clear, colorless |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- BD3480000
- CHEMICAL NAME :
- Alytesin, 2-L-glutamine-6-L-asparagine-
- CAS REGISTRY NUMBER :
- 31362-50-2
- LAST UPDATED :
- 199303
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C71-H110-N24-O18-S
- MOLECULAR WEIGHT :
- 1620.11
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 270,97,1992
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Safety Information
| Hazard Codes | F+ |
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| Safety Phrases | 22-24/25 |
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| WGK Germany | 3 |
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| RTECS | BD3480000 |
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Synonyms
| MFCD00167514 |
| Alphaxalone |
| bombesin acetate |
| bombesin acetate hydrate |
| M.W. 1619.85 C71H110N24O18S |
| pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 |
| BOMBESIN ACETATE SALT |
| BOMBESIN ACOH 7H2O |
| PYR-QRLGNQWAVGHLM-NH2 |
