Introduction：Basic information about CAS 149719-06-2|RS 23597-190, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RS 23597-190 |
|---|
| CAS Number | 149719-06-2 | Molecular Weight | 363.27900 |
|---|
| Density | / | Boiling Point | 486.5ºC at 760 mmHg |
|---|
| Molecular Formula | C16H24Cl2N2O3 | Melting Point | / |
|---|
| MSDS | Chinese | Flash Point | 248ºC |
|---|
Names
| Name | 3-piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride |
|---|
| Synonym | More Synonyms |
|---|
RS 23597-190 BiologicalActivity
| Description | RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
|---|
| Target | 5-HT4 Receptor |
|---|
| In Vitro | RS 23597-190 (10 µM; 4 days) 在高葡萄糖 (30 mM)条件下显着抑制661W 细胞中超氧化物的产生[2]。 |
|---|
| In Vivo | RS 23597-190 (6.0 mg/kg；静脉注射) 抑制微型猪中 5-HT 诱导的心动过速[1]. Animal Model: Bilaterally vagotomized micropig[1] Dosage: 6.0 mg/kg Administration: I.v. Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min. |
|---|
| References | [1]. Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26. [2]. Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204. |
|---|
Chemical & Physical Properties
| Boiling Point | 486.5ºC at 760 mmHg |
|---|
| Molecular Formula | C16H24Cl2N2O3 |
|---|
| Molecular Weight | 363.27900 |
|---|
| Flash Point | 248ºC |
|---|
| Exact Mass | 362.11600 |
|---|
| PSA | 64.79000 |
|---|
| LogP | 4.28470 |
|---|
| Vapour Pressure | 1.29E-09mmHg at 25°C |
|---|
| InChIKey | QLZLBYYNMGQIAR-UHFFFAOYSA-N |
|---|
| SMILES | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCCCC1.Cl |
|---|
Safety Information
| Hazard Codes | Xn |
|---|
| HS Code | 2933399090 |
|---|
Customs
| HS Code | 2933399090 |
|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
