CAS 499-04-7|Arecaidine

Introduction：Basic information about CAS 499-04-7|Arecaidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Arecaidine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Arecaidine
CAS Number	499-04-7	Molecular Weight	141.168
Density	1.2±0.1 g/cm3	Boiling Point	266.7±35.0 °C at 760 mmHg
Molecular Formula	C₇H₁₁NO₂	Melting Point	232ºC (dec.)
MSDS	/	Flash Point	115.1±25.9 °C

Names

Name	1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
Synonym	More Synonyms

Arecaidine BiologicalActivity

Description	Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Description

Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor

References

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	266.7±35.0 °C at 760 mmHg
Melting Point	232ºC (dec.)
Molecular Formula	C₇H₁₁NO₂
Molecular Weight	141.168
Flash Point	115.1±25.9 °C
Exact Mass	141.078979
PSA	40.54000
LogP	0.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.524
InChIKey	DNJFTXKSFAMXQF-UHFFFAOYSA-N
SMILES	CN1CCC=C(C(=O)O)C1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2070800

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-

CAS REGISTRY NUMBER :: 499-04-7

BEILSTEIN REFERENCE NO. :: 0112366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H11-N-O2

MOLECULAR WEIGHT :: 141.19

WISWESSER LINE NOTATION :: T6N CUTJ A1 CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,501,1984

Safety Information

HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid

1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Arecaidine

1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid

3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-

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