CAS 70553-45-6|NS 3763
| Common Name | NS 3763 | ||
|---|---|---|---|
| CAS Number | 70553-45-6 | Molecular Weight | 404.37200 |
| Density | 1.485g/cm3 | Boiling Point | 490.7ºC at 760 mmHg |
| Molecular Formula | C22H16N2O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 250.6ºC |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | 4,6-dibenzamidobenzene-1,3-dicarboxylic acid |
|---|---|
| Synonym | More Synonyms |
NS 3763 BiologicalActivity
| Description | NS3763 is a selective and noncompetitive GLUK5 receptor antagonist with an IC50 of 1.6 µM. NS3763 does not show significant antagonistic properties on GLUK6, AMPA or NMDA receptors[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
| Target | IC50: 1.6 µM (GLUK5 receptor)[1] |
| In Vitro | In human embryonic kidney HEK293 cells expressing homomeric GLUK5 or GLUK6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC50 = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC50 > 30 µM)[1]. NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLUK5 receptors in HEK293 cells[1]. |
| References | [1]. Jeppe K Christensen, et al. In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J Pharmacol Exp Ther. 2004 Jun;309(3):1003-10. |
Chemical & Physical Properties
| Density | 1.485g/cm3 |
|---|---|
| Boiling Point | 490.7ºC at 760 mmHg |
| Molecular Formula | C22H16N2O6 |
| Molecular Weight | 404.37200 |
| Flash Point | 250.6ºC |
| Exact Mass | 404.10100 |
| PSA | 132.80000 |
| LogP | 3.73360 |
| Index of Refraction | 1.735 |
| InChIKey | UUDYZUDTQPLDDP-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cc(NC(=O)c2ccccc2)c(C(=O)O)cc1C(=O)O)c1ccccc1 |
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H410 |
| Precautionary Statements | P261-P273-P305 + P351 + P338-P501 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi,N |
| Risk Phrases | 36/37/38-50/53 |
| Safety Phrases | 26-36-60-61 |
| RIDADR | UN 3077 9/PG 3 |
Articles7
More Articles| Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Mol. Cell. Biol. 29 , 3881-93, (2009) In Caenorhabditis elegans, the central cell-killing process is essentially controlled by the interplay of four apoptotic factors: EGL-1/BH3-only protein, CED-9/Bcl2, CED-4/Apaf1, and CED-3/caspase. In... | |
| Neurotoxic effects of TDP-43 overexpression in C. elegans. Hum. Mol. Genet. 19 , 3206-18, (2010) RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expr... | |
| Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J. Cell Biol. 124 , 1510-8, (2011) Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell ... |
Synonyms
| NS3763 |
| 5-Carboxy-2,4-dibenzamidobenzoic acid |
