CAS 143675-79-0|G Protein Antagonist

Introduction:Basic information about CAS 143675-79-0|G Protein Antagonist, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameG Protein Antagonist
CAS Number143675-79-0Molecular Weight1093.26000
Density/Boiling Point/
Molecular FormulaC57H64N12O9SMelting Point/
MSDSChineseUSAFlash Point/

Names

NameG-Protein antagonist peptide
SynonymMore Synonyms

G Protein Antagonist BiologicalActivity

DescriptionG-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
Related CatalogSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor

Chemical & Physical Properties

Molecular FormulaC57H64N12O9S
Molecular Weight1093.26000
Exact Mass1092.46000
PSA362.55000
LogP6.16720
InChIKeyWSYRBHQWMXTCHQ-SFIKJRKMSA-N
SMILESCSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(N)=O

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases22-24/25
RIDADRNONH for all modes of transport
WGK Germany3

Articles1

More Articles
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.

J. Biol. Chem. 267 , 16237, (1992)

A substance P (SP) analog, [D-Pro4,D-Trp7,9,10] SP4-11, is known to inhibit the actions of various structurally unrelated messenger molecules as well as SP. Our studies on the effects of this peptide ...

Synonyms

PYR-GLN-D-TRP-PHE-D-TRP-D-TRP-MET-NH2
pglu-gln-d-trp-phe-d-trp-d-trp-met-nh2
G PROTEIN ANTAGONIST
PROTEIN G ANTAGONIST 2
GP ANTAGONIST-2
pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2
[pGlu5,D-Trp7,9,10]-Substance P Fragment 5-11
G-PROTEIN ANTAGONIST-2
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