CAS 4452-06-6|ZM 449829

Introduction：Basic information about CAS 4452-06-6|ZM 449829, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ZM 449829 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	ZM 449829
CAS Number	4452-06-6	Molecular Weight	182.218
Density	1.1±0.1 g/cm3	Boiling Point	319.3±15.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀O	Melting Point	/
MSDS	/	Flash Point	137.5±15.3 °C

Names

Name	naphthyl vinyl ketone
Synonym	More Synonyms

ZM 449829 BiologicalActivity

Description	ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].
Related Catalog	Signaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKResearch Areas >>Inflammation/Immunology
Target	JAK3:6.8 (pIC50)
In Vitro	ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2]. Western Blot Analysis[2] Cell Line: YTS, NK92, and ex vivo NK cells Concentration: 1 μM Incubation Time: 30 minutes pretreatment Result: Inhibits the phosphorylation of STAT5.
References	[1]. Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010(6)575-9. [2]. Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr; 121(4): 1535-48.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	319.3±15.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀O
Molecular Weight	182.218
Flash Point	137.5±15.3 °C
Exact Mass	182.073166
PSA	17.07000
LogP	3.11
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.619
InChIKey	FOTCGZPFSUWZBN-UHFFFAOYSA-N
SMILES	C=CC(=O)c1ccc2ccccc2c1

Safety Information

HS Code	2914399090

Customs

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Synonyms

1-(2-naphthyl)prop-2-en-1-one

1-b-Naphthylpiperazine

2-Propen-1-one, 1-(2-naphthalenyl)-

3-naphthyl piperazine

vinyl phenyl ketone

1-(2-Naphthyl)-2-propen-1-one

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