CAS 56290-94-9|5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylam

Introduction：Basic information about CAS 56290-94-9|5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	5-[2-[[3-(1,3-benzodioxol-5-yl)-1-methylpropyl]amino]-1-hydroxyethyl]salicylamide
CAS Number	56290-94-9	Molecular Weight	372.41500
Density	1.307g/cm3	Boiling Point	604.1ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅	Melting Point	/
MSDS	/	Flash Point	319.1ºC

Names

Name	5-[2-[4-(1,3-benzodioxol-5-yl)butan-2-ylamino]-1-hydroxyethyl]-2-hydroxybenzamide
Synonym	More Synonyms

BiologicalActivity

Description	Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
In Vitro	Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip[1]. Cell Viability Assay[1] Cell Line: Isolated rabbit aortic strip Concentration: 0.1-10 μM Incubation Time: 20 min Result: Showed pA2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively.
In Vivo	Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats[1]. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 12.5, 25, or 50 mg/kg Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days Result: Produced a dose-related fall in blood pressure.

Chemical & Physical Properties

Density	1.307g/cm3
Boiling Point	604.1ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₅
Molecular Weight	372.41500
Flash Point	319.1ºC
Exact Mass	372.16900
PSA	114.04000
LogP	2.95530
Index of Refraction	1.626
InChIKey	MPQWSYJGFLADEW-UHFFFAOYSA-N
SMILES	CC(CCc1ccc2c(c1)OCO2)NCC(O)c1ccc(O)c(C(N)=O)c1

Synonyms

RMI 81,968

MEDROXALOL

EINECS 260-099-3

Medroxalolum

Recommended......