CAS 271-44-3|1H-Indazole

Introduction：Basic information about CAS 271-44-3|1H-Indazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 1H-Indazole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	1H-Indazole
CAS Number	271-44-3	Molecular Weight	118.136
Density	1.2±0.1 g/cm3	Boiling Point	270.0±9.0 °C at 760 mmHg
Molecular Formula	C₇H₆N₂	Melting Point	145-148 °C(lit.)
MSDS	/	Flash Point	128.5±11.7 °C

Names

Name	1H-indazole
Synonym	More Synonyms

1H-Indazole BiologicalActivity

Description	Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].
Related Catalog	Signaling Pathways >>Stem Cell/Wnt >>GSK-3Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Autophagy >>LRRK2Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological DiseaseSignaling Pathways >>PI3K/Akt/mTOR >>GSK-3
In Vitro	Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents[1]. Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)[2]. Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders[4].
References	[1]. Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21(5):363-376. [2]. Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22(14):1136-1151. [3]. Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22(14):1177-1188. [4]. Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22(14):1189-1214. [5]. Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21(7):839-860.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	270.0±9.0 °C at 760 mmHg
Melting Point	145-148 °C(lit.)
Molecular Formula	C₇H₆N₂
Molecular Weight	118.136
Flash Point	128.5±11.7 °C
Exact Mass	118.053101
PSA	28.68000
LogP	1.82
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.697
InChIKey	BAXOFTOLAUCFNW-UHFFFAOYSA-N
SMILES	c1ccc2[nH]ncc2c1
Water Solubility	SOLUBLE IN HOT WATER

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7745000

CHEMICAL NAME :: 1H-Indazole

CAS REGISTRY NUMBER :: 271-44-3

LAST UPDATED :: 199501

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BMNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

Safety Information

Hazard Codes	Xi
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	NK7745000
HS Code	29339990

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

isoindazole

Indazole

1H-Indazole

indazole-

MFCD00005691

EINECS 205-978-4

1,2-Benzopyrazole

1h-indazol

1,2-Benzodiazole

BENZOPYRAZOLE

Indazol

2-Azaindole

benzodiazole

Recommended......