Introduction：Basic information about CAS 117976-90-6|Rabeprazole sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.Target: Proton PumpRabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.
Related Catalog
Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Inflammation/Immunology
References
[1]. http://www.drugbank.ca/drugs/DB01129
Chemical & Physical Properties
Density
0.45~0.55 g/ml
Boiling Point
603.9ºC at 760 mmHg
Melting Point
140-141ºC dec.
Molecular Formula
C18H20N3NaO3S
Molecular Weight
381.424
Flash Point
319.1ºC
Exact Mass
381.112305
PSA
93.41000
LogP
3.48420
InChIKey
KRCQSTCYZUOBHN-UHFFFAOYSA-N
SMILES
COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C.[Na+]
Storage condition
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Water Solubility
H2O: soluble10mg/mL (clear solution)
Safety Information
RIDADR
NONH for all modes of transport
HS Code
2933399090
Customs
HS Code
2933399090
Summary
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles3
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