CAS 438-67-5|Estrone sulfate sodium

Introduction：Basic information about CAS 438-67-5|Estrone sulfate sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Estrone sulfate sodium BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles30
7. Synonyms

Common Name	Estrone sulfate sodium
CAS Number	438-67-5	Molecular Weight	372.41
Density	1.349 g/cm3	Boiling Point	/
Molecular Formula	C₁₈H₂₁NaO₅S	Melting Point	258-260°C
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS08	Signal Word	Danger

Names

Name	estrone sodium sulfate
Synonym	More Synonyms

Estrone sulfate sodium BiologicalActivity

Description	Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
Related Catalog	Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer
Target	Human Endogenous Metabolite
In Vitro	T47D cells are stably transfected with SOAT and incubated under increasing concentrations of Estrone sulfate and estradiol at physiologically relevant concentrations. Cell proliferation is significantly increased by 1 nM estradiol as well as by Estrone sulfate with EC50 of 2.2 nM[3].
References	[1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303. [3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.

Chemical & Physical Properties

Density	1.349 g/cm3
Melting Point	258-260°C
Molecular Formula	C₁₈H₂₁NaO₅S
Molecular Weight	372.41
Exact Mass	372.100739
PSA	91.88000
LogP	4.03160
InChIKey	VUCAHVBMSFIGAI-ZFINNJDLSA-M
SMILES	CC12CCC3c4ccc(OS(=O)(=O)[O-])cc4CCC3C1CCC2=O.[Na+]
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG8775000

CHEMICAL NAME :: Estrone, hydrogen sulfate, sodium salt

CAS REGISTRY NUMBER :: 438-67-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-O5-S.Na

MOLECULAR WEIGHT :: 373.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 504 ug/kg

SEX/DURATION :: female 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 55,191,1979

Safety Information

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H335-H350
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	R45-36/37/38
Safety Phrases	S53-45-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG8775000

Articles30

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

J. Pharm. Sci. 102(1) , 280-8, (2013)

We aimed to explore the major active components in grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ) that are responsible for OATP2B1-mediated drug interactions, by means of in vitro stu...

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.

Drug Metab. Dispos. 43(2) , 284-8, (2015)

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell li...

Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.

J. Clin. Oncol. 32(28) , 3111-7, (2014)

Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma es...

Synonyms

Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1)

Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate

Estrone 3-sulfate sodium salt

Estrone sodium sulfate

Estrone sulfate sodium

Estrone-3-sulfate sodium salt

estrone sodium sulphate

Sodium estrone 3-sulfate

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