CAS 469-38-5|CYCLOARTENOL

Introduction：Basic information about CAS 469-38-5|CYCLOARTENOL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CYCLOARTENOL BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	CYCLOARTENOL
CAS Number	469-38-5	Molecular Weight	426.71700
Density	1.01 g/cm3	Boiling Point	505.5ºC at 760 mmHg
Molecular Formula	C₃₀H₅₀O	Melting Point	115-117ºC
MSDS	/	Flash Point	221.9ºC

Names

Name	cycloartenol
Synonym	More Synonyms

CYCLOARTENOL BiologicalActivity

Description	Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPK
In Vitro	Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].
References	[1]. Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23(6):1840-1845. [2]. Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437.

Chemical & Physical Properties

Density	1.01 g/cm3
Boiling Point	505.5ºC at 760 mmHg
Melting Point	115-117ºC
Molecular Formula	C₃₀H₅₀O
Molecular Weight	426.71700
Flash Point	221.9ºC
Exact Mass	426.38600
PSA	20.23000
LogP	8.16890
Vapour Pressure	2.47E-12mmHg at 25°C
Index of Refraction	1.538
InChIKey	ONQRKEUAIJMULO-SBAQNCMESA-N
SMILES	CC(C)=CCCC(C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC45CC35CCC12C

Safety Information

Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25

Synonyms

CYCLOARTENOL

9,19-Cyclolanost-24-en-3-ol

9,19-CYCLO-9BETA-LANOST-24-EN-3BETA-OL

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