Introduction：Basic information about CAS 521-34-6|Amentoflavone-4',4",7-trimethyl Ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amentoflavone-4',4",7-trimethyl Ether |
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| CAS Number | 521-34-6 | Molecular Weight | 580.538 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 839.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C33H24O10 | Melting Point | 296-298ºC |
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| MSDS | / | Flash Point | 276.2±27.8 °C |
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Names
| Name | sciadopitysin |
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| Synonym | More Synonyms |
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Amentoflavone-4',4",7-trimethyl Ether BiologicalActivity
| Description | Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| Target | NF-κB |
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| In Vitro | Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2]. |
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| In Vivo | Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2]. |
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| References | [1]. Briançon-Scheid F, et al. HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. Planta Med. 1983 Dec;49(12):204-7. [2]. Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents boneloss in LPS-treated mice. Int Immunopharmacol. 2017 Aug;49:109-117. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 839.6±65.0 °C at 760 mmHg |
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| Melting Point | 296-298ºC |
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| Molecular Formula | C33H24O10 |
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| Molecular Weight | 580.538 |
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| Flash Point | 276.2±27.8 °C |
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| Exact Mass | 580.136963 |
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| PSA | 148.80000 |
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| LogP | 5.50 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.684 |
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| InChIKey | YCXRBCHEOFVYEN-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(O)cc(O)c(-c4cc(-c5cc(=O)c6c(O)cc(OC)cc6o5)ccc4OC)c3o2)cc1 |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 24/25 |
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| HS Code | 29329990 |
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Synonyms
| Amentoflavone-4',4",7-trimethyl Ether |
| I-7,I-4',II-4'-tri-O-methylamentoflavone |
| Amentoflavone-7,4',4'''-trimethyl ether |
| 5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one |
| Sciadopitysin |
| 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one |
| 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)- |
| Sciadopytissin |
| Jin Song biflavone |
