Introduction：Basic information about CAS 742-20-1|cyclopenthiazide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | cyclopenthiazide |
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| CAS Number | 742-20-1 | Molecular Weight | 379.883 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 605.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C13H18ClN3O4S2 | Melting Point | 238-242ºC |
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| MSDS | / | Flash Point | 320.1±34.3 °C |
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Names
| Name | Cyclopenthiazide |
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| Synonym | More Synonyms |
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cyclopenthiazide BiologicalActivity
| Description | Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | Cyclopenthiazide (0.5 mg/kg; i.p.; daily, for 3 days; female Wistar rats) increases the excretion of p-aminohippurate (PAH) [1]. Animal Model: Female Wistar rats[1] Dosage: 0.5 mg/kg Administration: Intraperitoneal injection; daily, for 3 days Result: Stimulated p-aminohippurate (PAH) excretion. |
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| References | [1]. Bräunlich H. Postnatal development of kidney function in rats receiving thyroid hormones. Exp Clin Endocrinol. 1984 May;83(3):243-50. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 605.6±65.0 °C at 760 mmHg |
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| Melting Point | 238-242ºC |
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| Molecular Formula | C13H18ClN3O4S2 |
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| Molecular Weight | 379.883 |
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| Flash Point | 320.1±34.3 °C |
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| Exact Mass | 379.042725 |
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| PSA | 135.12000 |
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| LogP | 1.58 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.601 |
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| InChIKey | BKYKPTRYDKTTJY-UHFFFAOYSA-N |
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| SMILES | NS(=O)(=O)c1cc2c(cc1Cl)NC(CC1CCCC1)NS2(=O)=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DK8750000
- CHEMICAL NAME :
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 742-20-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C13-H18-Cl-N3-O4-S2
- MOLECULAR WEIGHT :
- 379.91
- WISWESSER LINE NOTATION :
- T66 BSWM EM DHJ HG ISZW D1- AL5TJ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 142 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,325,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 232 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,325,1961
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Safety Information
Synonyms
| UNII:VX4S2N85F5 |
| UNII:T7817XC41U |
| EINECS 212-012-5 |
| cyclopenthiazide |
| 6-Chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide |
| UNII:866GEV195O |
| 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide |
| 3-Cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide |
| 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide |
| Benesal (VAN) |
| 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide |
| MFCD00865825 |
| Tsiklometiazid |
