CAS 480-20-6|Aromadendrin
| Common Name | Aromadendrin | ||
|---|---|---|---|
| CAS Number | 480-20-6 | Molecular Weight | 288.252 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 639.0±55.0 °C at 760 mmHg |
| Molecular Formula | C15H12O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 247.3±25.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (+)-dihydrokaempferol |
|---|---|
| Synonym | More Synonyms |
Aromadendrin BiologicalActivity
| Description | Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/Immunology |
| Target | Apoptosis; Bcl-2; Bcl-xL[1] |
| In Vitro | Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1]. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1]. Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression. |
| References | [1]. Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 639.0±55.0 °C at 760 mmHg |
| Molecular Formula | C15H12O6 |
| Molecular Weight | 288.252 |
| Flash Point | 247.3±25.0 °C |
| Exact Mass | 288.063385 |
| PSA | 107.22000 |
| LogP | 2.42 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.729 |
| InChIKey | PADQINQHPQKXNL-LSDHHAIUSA-N |
| SMILES | O=C1c2c(O)cc(O)cc2OC(c2ccc(O)cc2)C1O |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | N,Xn |
| Risk Phrases | 50-22 |
| Safety Phrases | 61 |
| RIDADR | UN 3077 9 / PGIII |
Articles28
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| Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity. FEBS Lett. 588(14) , 2307-14, (2014) FNS I is a 2-oxoglutarate dependent dioxygenase (2-ODD) found mainly in species of the Apiaceae family. Here, an FNS I cDNA sequence was isolated from the liverwort Plagiochasma appendiculatum (Aytoni... | |
| Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli. Appl. Environ. Microbiol. 78(3) , 684-94, (2012) 7-O-Methyl aromadendrin (7-OMA) is an aglycone moiety of one of the important flavonoid-glycosides found in several plants, such as Populus alba and Eucalyptus maculata, with various medicinal applica... |
Synonyms
| 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R-trans)- |
| Katuranin |
| (2R,3R)-3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one |
| (+)-dihydrokaempferol |
| Aromadedrin |
| Aromadendrin |
| 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)- |
| DIHYDROKAEMPFEROL |
