CAS 37693-01-9|Clofoctol

Introduction：Basic information about CAS 37693-01-9|Clofoctol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Clofoctol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles20
7. Synonyms

Common Name	Clofoctol
CAS Number	37693-01-9	Molecular Weight	365.33700
Density	1.127 g/cm3	Boiling Point	447.7ºC at 760 mmHg
Molecular Formula	C₂₁H₂₆Cl₂O	Melting Point	78°
MSDS	ChineseUSA	Flash Point	160.4ºC

Names

Name	2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
Synonym	More Synonyms

Clofoctol BiologicalActivity

Description	Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. It is only functional against Gram-positive bacteria, It penetrates into human lung tissue.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

Chemical & Physical Properties

Density	1.127 g/cm3
Boiling Point	447.7ºC at 760 mmHg
Melting Point	78°
Molecular Formula	C₂₁H₂₆Cl₂O
Molecular Weight	365.33700
Flash Point	160.4ºC
Exact Mass	364.13600
PSA	20.23000
LogP	7.00360
Index of Refraction	1.555
InChIKey	HQVZOORKDNCGCK-UHFFFAOYSA-N
SMILES	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0533000

CHEMICAL NAME :: Phenol, 2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethyl butyl)-

CAS REGISTRY NUMBER :: 37693-01-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H26-Cl2-O

MOLECULAR WEIGHT :: 365.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3830852

Safety Information

RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	SL0533000

Articles20

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Br. J. Pharmacol. 171(19) , 4478-89, (2014)

Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate drug discovery and development. The unfolded protein response pathways...

A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.

Drugs Exp. Clin. Res. 14(1) , 39-43, (1988)

A microbiological assay was undertaken to measure the amounts of clofoctol in human plasma and pulmonary tissue, and to investigate its pharmacokinetics. Clofoctol was extracted from samples using eth...

Alteration of membrane permeability in Bacillus subtilis by clofoctol.

J. Gen. Microbiol. 129(4) , 1089-95, (1983)

When Bacillus subtilis was treated with a bacteriostatic concentration of clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-1,1,3,3-butyl)phenol], UV-absorbing material was released. Electron micrograp...

Synonyms

EINECS 253-632-6

2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)phenol

Clofoctolum

Octofene

clofoctol

Recommended......