CAS 68813-55-8|Oxantel (pamoate)
| Common Name | Oxantel (pamoate) | ||
|---|---|---|---|
| CAS Number | 68813-55-8 | Molecular Weight | 604.65 |
| Density | 1.09 g/cm3 | Boiling Point | 383.1ºC at 760 mmHg |
| Molecular Formula | C36H32N2O7 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 185.5ºC |
Names
| Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol |
|---|---|
| Synonym | More Synonyms |
Oxantel (pamoate) BiologicalActivity
| Description | Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
| Target | Antiparasitic[1] |
| In Vivo | The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1]. |
| References | [1]. Keiser J, et al. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119. |
Chemical & Physical Properties
| Density | 1.09 g/cm3 |
|---|---|
| Boiling Point | 383.1ºC at 760 mmHg |
| Molecular Formula | C36H32N2O7 |
| Molecular Weight | 604.65 |
| Flash Point | 185.5ºC |
| PSA | 186.72000 |
| LogP | 7.41720 |
| Storage condition | -20℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles7
More Articles| Oxantel pamoate-albendazole for Trichuris trichiura infection. N. Engl. J. Med. 370(7) , 610-20, (2014) Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated... | |
| Preventive anthelmintic chemotherapy--expanding the armamentarium. N. Engl. J. Med. 370(7) , 665-6, (2014) | |
| Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection. Am. J. Physiol. Gastrointest. Liver Physiol. 299 , G1354-G1360, (2010) Irritable bowel syndrome (IBS) is common in countries where chronic parasitic infestations are endemic. However, the relationship between parasitic infection and IBS is not clear. The aim of this stud... |
Synonyms
| Telopar (TN) |
| EINECS 272-332-6 |
| UNII-UPY1D732T0 |
| Telopar |
| HMS2093L04 |
| Oxantel embonate |
| Oxantel pamoate (USAN) |
| OXANTEL PAMOATE |
| Oxantel (pamoate) |
