CAS 489-84-9|guaiazulene

Introduction：Basic information about CAS 489-84-9|guaiazulene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. guaiazulene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	guaiazulene
CAS Number	489-84-9	Molecular Weight	198.303
Density	0.976	Boiling Point	305.4±22.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₈	Melting Point	27-29 °C(lit.)
MSDS	/	Flash Point	142.3±13.1 °C

Names

Name	guaiazulene
Synonym	More Synonyms

guaiazulene BiologicalActivity

Description	Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49(9):938-42. [2]. Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):29-33.

Description

Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49(9):938-42.

[2]. Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):29-33.

Chemical & Physical Properties

Density	0.976
Boiling Point	305.4±22.0 °C at 760 mmHg
Melting Point	27-29 °C(lit.)
Molecular Formula	C₁₅H₁₈
Molecular Weight	198.303
Flash Point	142.3±13.1 °C
Exact Mass	198.140854
LogP	5.71
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.573
InChIKey	FWKQNCXZGNBPFD-UHFFFAOYSA-N
SMILES	Cc1ccc(C(C)C)cc2c(C)ccc1-2
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CO4790000

CHEMICAL NAME :: Azulene, 1,4-dimethyl-7-isopropyl-

CAS REGISTRY NUMBER :: 489-84-9

BEILSTEIN REFERENCE NO. :: 1365001

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H18

MOLECULAR WEIGHT :: 198.33

WISWESSER LINE NOTATION :: L57J B1 F1 IY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,362,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,362,1958

Safety Information

Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36/37/39-S26-S22
WGK Germany	3
RTECS	CO4790000

Synonyms

1,4-Dimethyl-7-(propan-2-yl)azulen

Guajazulene

Azulene, 1,4-dimethyl-7-(1-methylethyl)-

1,4-dimethyl-7-propan-2-ylazulene

Cuteazul

Gurjunazulen

Eucazulen

Vetivazulen

Azulon

Vaumigan

Azulene, 1,4-dimethyl-7- (1-methylethyl)-

EINECS 207-701-2

MFCD00003811

7-Isopropyl-1,4-dimethylazulene

guaiazulene

1,4-Dimethyl-7-isopropylazulene (JAN)

1,4-Dimethyl-7-isopropylazulene

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