Introduction：Basic information about CAS 56932-43-5|NSC-87877 disodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC-87877 disodium |
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| CAS Number | 56932-43-5 | Molecular Weight | 503.41600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C19H11N3Na2O7S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 8-hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt |
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| Synonym | More Synonyms |
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NSC-87877 disodium BiologicalActivity
| Description | NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphatase |
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| Target | IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1]. |
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| In Vitro | NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3]. NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3]. Cell Viability Assay[2] Cell Line: p53 wild-type neuroblastoma (NB) cell lines. Concentration: 0, 0.25, 0.5 μM. Incubation Time: 5 days. Result: Resulted in increased p53 phosphorylation (Ser37 and Ser46) and activation, increased activation of downstream p38 effector proteins (heat shock protein 27 (HSP27) and MAP kinase-activated protein kinase 2 (MAPKAPK2)) and poly ADP ribose polymerase/caspase-3 cleavage. Inhibited DUSP26 function in NB cell lines. Resulted in apoptosis in many cell lines at varying IC50 levels of 1.84 μM (IMR32), 6.35 μM (SK-N-SH), 8.69 μM (NB-19), 12.6 μM (SMS-KCN), 15.7 μM (SH-SY5Y), 15.8 μM (JF) and 19.0 μM (CHLA-225), respectively. |
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| In Vivo | NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3]. Animal Model: Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3]. Dosage: 30 mg/kg. Administration: IP once daily for 15 days. Result: Significantly inhibited NB tumor growth. |
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| References | [1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. [2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. [3]. Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. |
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Chemical & Physical Properties
| Molecular Formula | C19H11N3Na2O7S2 |
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| Molecular Weight | 503.41600 |
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| Exact Mass | 502.98300 |
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| PSA | 189.00000 |
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| LogP | 5.47880 |
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| InChIKey | IFVGQKHFUZRWNA-UHFFFAOYSA-L |
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| SMILES | O=S(=O)([O-])c1ccc2cc(N=Nc3cc(S(=O)(=O)[O-])c4cccnc4c3O)ccc2c1.[Na+].[Na+] |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| naphthylazoxine s |
| naphthylazoxine 6s |
| naphthylazoxine s disodium salt |
| EINECS 260-449-5 |
| NSC87877 |
