CAS 153212-75-0|6α-Hydroxy paclitaxel
Introduction：Basic information about CAS 153212-75-0|6α-Hydroxy paclitaxel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6α-Hydroxy paclitaxel | ||
|---|---|---|---|
| CAS Number | 153212-75-0 | Molecular Weight | 869.906 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 979.8±65.0 °C at 760 mmHg |
| Molecular Formula | C47H51NO15 | Melting Point | 177-180ºC |
| MSDS | / | Flash Point | 546.4±34.3 °C |
Names
| Name | 6-hydroxypaclitaxel |
|---|---|
| Synonym | More Synonyms |
6α-Hydroxy paclitaxel BiologicalActivity
| Description | 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| References | [1]. Mori D, et al. Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel. Drug Metab Dispos. 2020 May;48(5):387-394. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 979.8±65.0 °C at 760 mmHg |
| Melting Point | 177-180ºC |
| Molecular Formula | C47H51NO15 |
| Molecular Weight | 869.906 |
| Flash Point | 546.4±34.3 °C |
| Exact Mass | 869.325867 |
| PSA | 241.52000 |
| LogP | 7.32 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.646 |
| InChIKey | NDCWHEDPSFRTDA-FJMWQILYSA-N |
| SMILES | CC(=O)OC1C(=O)C2(C)C(O)C(O)C3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C |
| Storage condition | 2-8°C |
Safety Information
| Hazard Codes | Xn |
|---|
Synonyms
| (2α,3ξ,5β,6α,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,6,7-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| 6α-Hydroxy Paclitaxel |
| Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4 a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
| Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,3S,4R,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,1 3,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
| 6-Hydroxytaxol |
| 6-hydroxypaclitaxel |
