Introduction：Basic information about CAS 53155-25-2|Euscaphic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Euscaphic acid |
|---|
| CAS Number | 53155-25-2 | Molecular Weight | 488.699 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 602.7±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C30H48O5 | Melting Point | 262-264℃ |
|---|
| MSDS | / | Flash Point | 332.3±28.0 °C |
|---|
Names
| Name | euscaphic acid |
|---|
| Synonym | More Synonyms |
|---|
Euscaphic acid BiologicalActivity
| Description | Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2]. |
|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3K |
|---|
| Target | IC50: 61 μM (calf DNA polymerase α); 108 μM (rat DNA polymerase β)[1]; apoptosis[2] |
|---|
| In Vitro | Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2]. |
|---|
| References | [1]. Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200. [2]. Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 602.7±55.0 °C at 760 mmHg |
|---|
| Melting Point | 262-264℃ |
|---|
| Molecular Formula | C30H48O5 |
|---|
| Molecular Weight | 488.699 |
|---|
| Flash Point | 332.3±28.0 °C |
|---|
| Exact Mass | 488.350189 |
|---|
| PSA | 97.99000 |
|---|
| LogP | 6.21 |
|---|
| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
|---|
| Index of Refraction | 1.580 |
|---|
| InChIKey | OXVUXGFZHDKYLS-QUFHAEKXSA-N |
|---|
| SMILES | CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1(C)O |
|---|
Safety Information
Synonyms
| Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3α)- |
| Jacarandic acid |
| (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| 2α,3α,19α-Trihydroxyurs-12-en-28-oic acid |
| (2α,3α)-2,3,19-Trihydroxyurs-12-en-28-oic acid |
| tormentic acid |
| Euscaphic acid |
| 2,3,19-trihydroxyurs-12-en-28-oic acid |
