Introduction：Basic information about CAS 7218-43-1|Propargyl-PEG2-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Propargyl-PEG2-OH |
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| CAS Number | 7218-43-1 | Molecular Weight | 144.168 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 225.6±20.0 °C at 760 mmHg |
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| Molecular Formula | C7H12O3 | Melting Point | / |
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| MSDS | / | Flash Point | 90.3±21.8 °C |
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Names
| Name | 2-(2-prop-2-ynoxyethoxy)ethanol |
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| Synonym | More Synonyms |
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Propargyl-PEG2-OH BiologicalActivity
| Description | Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 225.6±20.0 °C at 760 mmHg |
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| Molecular Formula | C7H12O3 |
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| Molecular Weight | 144.168 |
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| Flash Point | 90.3±21.8 °C |
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| Exact Mass | 144.078644 |
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| PSA | 38.69000 |
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| LogP | -0.61 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.453 |
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| InChIKey | HUSDTFBXUYBZJD-UHFFFAOYSA-N |
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| SMILES | C#CCOCCOCCO |
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Synonyms
| HUSDTFBXUYBZJD-UHFFFAOYSA |
| 2-[2-(2-Propyn-1-yloxy)ethoxy]ethanol |
| 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL |
| Propargyl-PEG3 |
| 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol |
| Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]- |
| propargyl-PEG2-OH |
| Ethanol,2-(2-(2-propynyloxy)ethoxy) |
| 3,6-dioxanon-8-yn-1-ol |
| ethanol, 2-(2-(2-propynyloxy)ethoxy)- |
| 2,6-DIMETHYLCYCLOHEXANOL |
| O-Prop-2-inyl-diaethylenglykol |
| 2-(2-Prop-2-inyloxy-aethoxy)-aethanol |
| 2-(2-prop-2-ynyloxy-ethoxy)-ethanol |
