Introduction：Basic information about CAS 1054629-49-0|AZD4694, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AZD4694 |
|---|
| CAS Number | 1054629-49-0 | Molecular Weight | 258.24800 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C14H11FN2O2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol |
|---|
| Synonym | More Synonyms |
|---|
AZD4694 BiologicalActivity
| Description | AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular Disease |
|---|
| Target | Kd: 2.3 nM (Aβ) |
|---|
| In Vivo | Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1]. AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1]. Animal Model: Male Sprague–Dawley rats (275-300 g)[1] Dosage: 4 mL/kg Administration: I.v. Result: Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. |
|---|
| References | [1]. Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. |
|---|
Chemical & Physical Properties
| Molecular Formula | C14H11FN2O2 |
|---|
| Molecular Weight | 258.24800 |
|---|
| Exact Mass | 258.08000 |
|---|
| PSA | 61.52000 |
|---|
| LogP | 2.80310 |
|---|
| InChIKey | MYNQXTDIPMCJCR-UHFFFAOYSA-N |
|---|
| SMILES | CNc1ccc(-c2cc3cc(O)ccc3o2)c(F)n1 |
|---|
Synonyms
