Introduction：Basic information about CAS 28282-25-9|Beta-Elemonic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Beta-Elemonic acid |
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| CAS Number | 28282-25-9 | Molecular Weight | 454.684 |
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| Density | 1.07 | Boiling Point | 565.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C30H46O3 | Melting Point | 216-219 ºC |
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| MSDS | ChineseUSA | Flash Point | 309.6±26.6 °C |
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Names
| Name | β-Elemonic acid |
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| Synonym | More Synonyms |
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Beta-Elemonic acid BiologicalActivity
| Description | β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
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| Target | COX-2 |
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| In Vitro | β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 µM[1]. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells[1]. |
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| References | [1]. Atta-ur-Rahman, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005 Feb;68(2):189-93. [2]. Wu TT, et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The roleof MAPK, ROS activation and glutathione depletion. Oncol Rep. 2016 Jan;35(1):227-34. |
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Chemical & Physical Properties
| Density | 1.07 |
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| Boiling Point | 565.2±50.0 °C at 760 mmHg |
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| Melting Point | 216-219 ºC |
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| Molecular Formula | C30H46O3 |
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| Molecular Weight | 454.684 |
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| Flash Point | 309.6±26.6 °C |
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| Exact Mass | 454.344696 |
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| PSA | 54.37000 |
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| LogP | 8.56 |
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| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
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| Index of Refraction | 1.542 |
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| InChIKey | XLPAINGDLCDYQV-UHFFFAOYSA-N |
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| SMILES | CC(C)=CCCC(C(=O)O)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(=O)C(C)(C)C1CC3 |
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| Storage condition | -20℃ |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| (5β,13α,14β,20S)-3-Oxolanosta-8,24-dien-21-oic acid |
| Lanosta-8,24-dien-21-oic acid, 3-oxo-, (5β,13α,14β,20S)- |
| (2S)-6-methyl-2-[(10S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-5-enoic acid |
| beta-Elemonic acid |
