Introduction：Basic information about CAS 72957-42-7|AMP PNP, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AMP PNP |
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| CAS Number | 72957-42-7 | Molecular Weight | 529.92900 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H13Li4N6O12P3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | tetralithium,[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate |
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| Synonym | More Synonyms |
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AMP PNP BiologicalActivity
| Description | AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| In Vitro | AMP-PNP (5 to 500 μM; Li salt) reduced the open-probability po of KATP channels and decreases the single-channel currents at high nucleotide concentrations by approximately 10%[2]. AMP-PNP inhibits KATP channels of ventricular myocytes and of pancreatic β-cells both in the absence and presence of Mg2+ ions[2]. |
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| References | [1]. I M Rybakowska, et al. Activities of purine converting enzymes in heart, liver and kidney mice LDLR-/- and Apo E-/. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):340-347. [2]. S Hehl, et al. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur Biophys J. 1994;23(4):231-7. |
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Chemical & Physical Properties
| Molecular Formula | C10H13Li4N6O12P3 |
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| Molecular Weight | 529.92900 |
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| Exact Mass | 530.04400 |
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| PSA | 322.68000 |
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| LogP | 0.66890 |
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| InChIKey | FDBDJIGGLGUOPP-KWIZKVQNSA-J |
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| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])OP(=O)([O-])NP(=O)([O-])[O-])C(O)C1O.[Li+].[Li+].[Li+].[Li+] |
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| Storage condition | -20°C |
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Safety Information
Synonyms
| tetralithium |
| Adenylyl imidodiphosphate tetralithium salt |
| MFCD03424105 |
| adenylyl-imidodiphosphate tetralithium |
| AMP-PNP |
| EINECS 277-127-5 |
