CAS 94825-44-2|Guanosine 5′-[γ-thio]triphosphate

Introduction：Basic information about CAS 94825-44-2|Guanosine 5′-[γ-thio]triphosphate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Guanosine 5′-[γ-thio]triphosphate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles2
6. Synonyms

Common Name	Guanosine 5′-[γ-thio]triphosphate
CAS Number	94825-44-2	Molecular Weight	562.97800
Density	/	Boiling Point	/
Molecular Formula	C₁₀H₁₂Li₄N₅O₁₃P₃S	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	tetralithium,[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
Synonym	More Synonyms

Guanosine 5′-[γ-thio]triphosphate BiologicalActivity

Description	GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73. [2]. Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200. [3]. Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49. [4]. Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54.

Description

GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73.

[2]. Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200.

[3]. Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49.

[4]. Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54.

Chemical & Physical Properties

Molecular Formula	C₁₀H₁₂Li₄N₅O₁₃P₃S
Molecular Weight	562.97800
Exact Mass	563.00100
PSA	354.87000
LogP	0.76530
InChIKey	AMQXJFWJOAWCPV-ZVQJTLEUSA-J
SMILES	Nc1nc2c(ncn2C2OC(COP(=O)([O-])OP(=O)([O-])OP([O-])([O-])=S)C(O)C2O)c(=O)[nH]1.[Li+].[Li+].[Li+].[Li+]
Storage condition	20°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Articles2

Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

Cell Physiol. Biochem. 21 , 1444-54, (2009)

There is a certain cross-talk in the nervous system between N-methyl-D-aspartate receptors (NMDARs) and Mu-opioid receptors (MORs). While NMDARs participate in the desensitization of MORs, these in tu...

High-level production and characterization of a G-protein coupled receptor signaling complex.

FASEB J. 276 , 4515-28, (2009)

Elucidation of the molecular details of signal transduction through G-protein coupled receptors (GPCRs) awaits the solution of high-resolution structures of the receptor species involved in passing th...

Synonyms

EINECS 305-606-1

GTP|AS tetralithium salt

MFCD00135151

GTP-|A-S-Li4

Guanosine5'-(Trihydrogen Diphosphate) P'-Anhydride With Phosphorothioic Acid Lithiumsalt (1:4)

Guanosine 5′-[γ-thio]triphosphate

Gtp-Gamma-S Tetralithium Salt

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