Introduction：Basic information about CAS 740-33-0|Mosloflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mosloflavone |
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| CAS Number | 740-33-0 | Molecular Weight | 298.290 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 508.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C17H14O5 | Melting Point | 163-164ºC (chloroform , acetone ) |
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| MSDS | / | Flash Point | 190.5±23.6 °C |
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Names
| Name | 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one |
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| Synonym | More Synonyms |
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Mosloflavone BiologicalActivity
| Description | Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| Target | IC50: EV71; bacterial[1][2] |
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| In Vitro | Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2]. |
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| References | [1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. [2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134. [3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 508.5±50.0 °C at 760 mmHg |
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| Melting Point | 163-164ºC (chloroform , acetone ) |
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| Molecular Formula | C17H14O5 |
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| Molecular Weight | 298.290 |
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| Flash Point | 190.5±23.6 °C |
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| Exact Mass | 298.084137 |
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| PSA | 68.90000 |
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| LogP | 2.74 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.622 |
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| InChIKey | SIVAITYPYQQYAP-UHFFFAOYSA-N |
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| SMILES | COc1cc2oc(-c3ccccc3)cc(=O)c2c(O)c1OC |
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Safety Information
Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one |
| 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one |
| baicalein 6,7-dimethyl ether |
| 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl- |
| Mosloflavone |
| 5-hydroxy-6,7-dimethoxyflavone |
