Introduction：Basic information about CAS 517885-72-2|Dehydroglyasperin D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dehydroglyasperin D |
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| CAS Number | 517885-72-2 | Molecular Weight | 368.42 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 557.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H24O5 | Melting Point | / |
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| MSDS | / | Flash Point | 291.2±30.1 °C |
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Names
| Name | 4-(5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl)benzene-1,3-diol |
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| Synonym | More Synonyms |
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Dehydroglyasperin D BiologicalActivity
| Description | Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Aldose ReductaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXResearch Areas >>Metabolic Disease |
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| Target | COX-2[1] |
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| References | [1]. Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33(5):917-21. [2]. Jung SK, et al. MLK3 is a novel target of dehydroglyasperin D for the reduction in UVB-induced COX-2 expression in vitro and in vivo. J Cell Mol Med. 2015 Jan;19(1):135-42. [3]. Baek EJ, et al. Dehydroglyasperin D Suppresses Melanin Synthesis through MITF Degradation in Melanocytes. J Microbiol Biotechnol. 2022 Aug 28;32(8):982-988. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 557.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H24O5 |
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| Molecular Weight | 368.42 |
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| Flash Point | 291.2±30.1 °C |
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| Exact Mass | 368.162384 |
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| PSA | 68.15000 |
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| LogP | 6.18 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.605 |
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| InChIKey | QHJJASRUTXHRAL-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(c(OC)c1CC=C(C)C)C=C(c1ccc(O)cc1O)CO2 |
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Safety Information
Synonyms
| 4-[(R)-5,7-Dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-3-yl]-benzene-1,3-diol |
| 4-((R)-5,7-Dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-3-yl)-benzene-1,3-diol |
| 1,3-Benzenediol, 4-[5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]- |
| 4-[5,7-Dimethoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-3-yl]-1,3-benzenediol |
