Introduction：Basic information about CAS 81045-50-3|Pivopril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pivopril |
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| CAS Number | 81045-50-3 | Molecular Weight | 329.45500 |
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| Density | 1.16g/cm3 | Boiling Point | 490.431°C at 760 mmHg |
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| Molecular Formula | C16H27NO4S | Melting Point | / |
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| MSDS | / | Flash Point | 250.4±26.8 °C |
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Names
| Name | (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine |
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| Synonym | More Synonyms |
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Pivopril BiologicalActivity
| Description | Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Cardiovascular Disease |
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| Target | ACE[1] |
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| In Vivo | Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2]. |
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| References | [1]. Burnier M, et al. RHC 3659: a new orally active angiotensin converting enzyme inhibitor in normal volunteers. Br J Clin Pharmacol. 1981 Dec;12(6):893-9. [2]. Wolf PS, et al. Angiotensin-converting enzyme inhibitory and antihypertensive activities of pivalopril (RHC 3659-(S)). Fed Proc. 1984 Apr;43(5):1322-5. |
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Chemical & Physical Properties
| Density | 1.16g/cm3 |
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| Boiling Point | 490.431°C at 760 mmHg |
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| Molecular Formula | C16H27NO4S |
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| Molecular Weight | 329.45500 |
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| Flash Point | 250.4±26.8 °C |
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| Exact Mass | 329.16600 |
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| PSA | 99.98000 |
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| LogP | 2.78420 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.531 |
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| InChIKey | XRKXJJYSKUIIEN-LLVKDONJSA-N |
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| SMILES | CC(CSC(=O)C(C)(C)C)C(=O)N(CC(=O)O)C1CCCC1 |
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| Storage condition | 2-8℃ |
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Synonyms
