Introduction：Basic information about CAS 566914-00-9|TLR1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TLR1 |
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| CAS Number | 566914-00-9 | Molecular Weight | 302.41100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H26N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Benzenepropanamide, N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl] |
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TLR1 BiologicalActivity
| Description | TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>MyD88 |
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| In Vitro | TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner[1]. |
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| In Vivo | TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)[1]. |
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| References | [1]. Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6. |
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Chemical & Physical Properties
| Molecular Formula | C18H26N2O2 |
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| Molecular Weight | 302.41100 |
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| Exact Mass | 302.19900 |
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| PSA | 49.41000 |
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| LogP | 2.71120 |
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| InChIKey | DAZSWUUAFHBCGE-KRWDZBQOSA-N |
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| SMILES | CC(C)C(NC(=O)CCc1ccccc1)C(=O)N1CCCC1 |
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