CAS 56512-49-3|Dabsyl chloride

Introduction：Basic information about CAS 56512-49-3|Dabsyl chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dabsyl chloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles31
8. Synonyms

Common Name	Dabsyl chloride
CAS Number	56512-49-3	Molecular Weight	323.79800
Density	1.29 g/cm3	Boiling Point	483.6ºC at 760 mmHg
Molecular Formula	C₁₄H₁₄ClN₃O₂S	Melting Point	185 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	246.3ºC
Symbol	GHS05	Signal Word	Danger

Names

Name	dabsyl chloride
Synonym	More Synonyms

Dabsyl chloride BiologicalActivity

Description	Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.
Related Catalog	Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others
In Vitro	Dabsyl chloride can give rise to mono-Dabsyl and bis-Dabsyl derivatives in the presence of multiple amino groups. Furthermore with respect to OPA derivatization, Dabsyl chloride can react with primary and also with secondary amines[1].
Cell Assay	Selected mouse brain samples from either cortical or striatal regions (100 mg wet weight) and neuroblastoma cells (SH-SY5Y) pellet derived from 25 cm2 flask are treated with 500 μL of 0.1 M HCl containing 0.2% TDGA, sonicated for 10 min (only for brain tissue), and then centrifuged at 14000 g for 30 min. The supernatant is freeze-dried. 50 μL of reaction buffer and 100 μL of 15 mM Dabsyl chloride are added to the tube and derivatized.
References	[1]. Francioso A, et al. HPLC Determination of Bioactive Sulfur Compounds, Amino Acids and Biogenic Amines in Biological Specimens. Adv Exp Med Biol. 2017;975:535-549.

Chemical & Physical Properties

Density	1.29 g/cm3
Boiling Point	483.6ºC at 760 mmHg
Melting Point	185 °C (dec.)(lit.)
Molecular Formula	C₁₄H₁₄ClN₃O₂S
Molecular Weight	323.79800
Flash Point	246.3ºC
Exact Mass	323.05000
PSA	70.48000
LogP	5.17630
Index of Refraction	1.607
InChIKey	VTVWTPGLLAELLI-UHFFFAOYSA-N
SMILES	CN(C)c1ccc(N=Nc2ccc(S(=O)(=O)Cl)cc2)cc1
Storage condition	−20°C
Water Solubility	DMF: soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB8927800

CHEMICAL NAME :: Benzenesulfonyl chloride, p-((p-(dimethylamino)phenyl)azo)-

CAS REGISTRY NUMBER :: 56512-49-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H14-Cl-N3-O2-S

MOLECULAR WEIGHT :: 323.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983

Safety Information

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C
Risk Phrases	R22;R34
Safety Phrases	S26-S36/37/39-S45-S27
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	DB8927800
Packaging Group	II
Hazard Class	8
HS Code	2927000090

Customs

HS Code	2927000090
Summary	2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles31

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry.

J. Mass Spectrom. 49(8) , 665-73, (2014)

Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical challenges. Since analytical tissue blanks do not ...

Lysine-directed staining of proteins for MS-based analyses.

Electrophoresis 34(3) , 401-4, (2013)

Visualization of proteins and MS-based analyses are elemental tasks in modern biochemistry. Nevertheless, reports about covalent protein dyes and their suitability for subsequent MS experiments remain...

Spectrophotometric determination of bacitracin in bulk drug as dabsyl derivative in a range of visible light.

Acta Pol. Pharm. 68(6) , 853-8, (2011)

A fast spectrophotometric method has been developed for bacitracin identification and determination after condensation reaction with dabsyl chloride. In addition, determination of dye stability of sul...

Synonyms

EINECS 260-235-1

4-[[4-(dimethylamino)phenyl]diazenyl]benzenesulfonyl chloride

MFCD00007444

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