CAS 66246-88-6|penconazole
Introduction：Basic information about CAS 66246-88-6|penconazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | penconazole | ||
|---|---|---|---|
| CAS Number | 66246-88-6 | Molecular Weight | 284.184 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 415.3±55.0 °C at 760 mmHg |
| Molecular Formula | C13H15Cl2N3 | Melting Point | 57.6-60.3ºC |
| MSDS | ChineseUSA | Flash Point | 204.9±31.5 °C |
| Symbol | GHS07, GHS08, GHS09 | Signal Word | Warning |
Names
| Name | penconazole |
|---|---|
| Synonym | More Synonyms |
penconazole BiologicalActivity
| Description | Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
| In Vivo | Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2]. Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation, in addition to the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats[2]. Animal Model: Twelve male Wistar rats[2] Dosage: 67 mg/kg Administration: I.p.; every 2 days during 9 days Result: A significant increase was obtained in the absolute and relative weights of the cerebrum and cerebellum, respectively. |
| References | [1]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8. [2]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 2017;36(8):854-866. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 415.3±55.0 °C at 760 mmHg |
| Melting Point | 57.6-60.3ºC |
| Molecular Formula | C13H15Cl2N3 |
| Molecular Weight | 284.184 |
| Flash Point | 204.9±31.5 °C |
| Exact Mass | 283.064301 |
| PSA | 30.71000 |
| LogP | 3.66 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.602 |
| InChIKey | WKBPZYKAUNRMKP-UHFFFAOYSA-N |
| SMILES | CCCC(Cn1cncn1)c1ccc(Cl)cc1Cl |
| Storage condition | 0-6°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,554,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2444 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984
Safety Information
| Symbol | GHS07, GHS08, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H361d-H410 |
| Precautionary Statements | P201-P273-P301 + P312 + P330-P308 + P313-P391-P501 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 3077 9 / PGIII |
| RTECS | XZ4615000 |
| HS Code | 2933990015 |
Customs
| HS Code | 2933990016 |
|---|---|
| Summary | 2933990016 1-(2-(2,4-dichlorophenyl)pentyl)-1h-1,2,4-triazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0% |
Articles24
More Articles| The dissipation of three fungicides in a biobed organic substrate and their impact on the structure and activity of the microbial community. Environ. Sci. Pollut. Res. Int. 20(4) , 2546-55, (2013) Biopurification systems (BPS) have been introduced to minimise the risk for point source contamination of natural water resources by pesticides. Their depuration efficiency relies mostly on the high b... | |
| Enantiomeric separation of triazole fungicides with 3-μm and 5-μml particle chiral columns by reverse-phase high-performance liquid chromatography. Chirality 23(6) , 479-86, (2011) This study used chiral columns packed with 3-μm and 5-μm particles to comparatively separate enantiomers of 9 triazole fungicides, and Lux Cellulose-1 columns with chiral stationary phase of cellulose... | |
| Biological monitoring of pesticide exposures in residents living near agricultural land. BMC Public Health 11 , 856, (2011) There is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessing pestic... |
Synonyms
| topasmz |
| (RS)-1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole |
| EINECS 266-275-6 |
| PENCONAZOL |
| T5NN DNJ A1Y3&R BG DG |
| 1-[2-(2,4-Dichlorophenyl)pentyl]-1H-1,2,4-triazole |
| onmex |
| MFCD00078737 |
| 1-[2-(2,4-Dichlorophenyl)-n-pentyl]-1H-1,2,4-triazole |
| Topas |
| 1-(2,4-Dichloro-β-propylphenethyl)-1H-1,2,4-triazole |
| topaze |
| 1H-1,2,4-Triazole, 1-[2-(2,4-dichlorophenyl)pentyl]- |
| topazec |
| penconazole |
| topasc |
| Pine gel |
| rac-1-[(2R)-2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole |
