CAS 107438-79-9|Ginkgolide J
| Common Name | Ginkgolide J | ||
|---|---|---|---|
| CAS Number | 107438-79-9 | Molecular Weight | 424.399 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 760.4±60.0 °C at 760 mmHg |
| Molecular Formula | C20H24O10 | Melting Point | 41-42 °C |
| MSDS | USA | Flash Point | 273.6±26.4 °C |
Names
| Name | Ginkgolide J |
|---|---|
| Synonym | More Synonyms |
Ginkgolide J BiologicalActivity
| Description | Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Apoptosis |
| In Vivo | Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by serum deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons[1]. |
| References | [1]. Ahlemeyer B, et al. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 2003 Jun; 36 Suppl 1:S8-14. [2]. Sylvia Pietri, et al. Synthesis and Biological Studies of a New Ginkgolide C Derivative: Evidence That the Cardioprotective Effect of Ginkgolides Is Unrelated to PAF Inhibition. DRUG DEVELOPMENT RESEARCH. 2001.54:191-201. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 760.4±60.0 °C at 760 mmHg |
| Melting Point | 41-42 °C |
| Molecular Formula | C20H24O10 |
| Molecular Weight | 424.399 |
| Flash Point | 273.6±26.4 °C |
| Exact Mass | 424.136932 |
| PSA | 148.82000 |
| LogP | -0.68 |
| Vapour Pressure | 0.0±5.8 mmHg at 25°C |
| Index of Refraction | 1.651 |
| InChIKey | LMEHVEUFNRJAAV-UKWFQYJJSA-N |
| SMILES | CC1C(=O)OC2CC34C5OC(=O)C3(OC3OC(=O)C(O)C34C(C(C)(C)C)C5O)C21O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
Articles11
More Articles| Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. Magn. Reson. Chem. 50(8) , 569-75, (2012) The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid... | |
| Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography. Se Pu 18(5) , 394-7, (2000) A new rapid analytical method was developed for the quantification of terpene lactones (bilobalide(BB) and ginkgolide A, B, C, J) in extract of Ginkgo biloba L. (EGb) using a liquid-liquid solvent ext... | |
| Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol. Aging 30(2) , 257-65, (2009) A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neu... |
Synonyms
| 6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b,10-trihydroxy-5-methyl-, (1R,3aR,4aR,4bR,5S,7aS,8aS,9S,10R,11S,11aS)- |
| (1R,3R,6R,7S,8S,9R,10S,11S,13S,16S,17R)-6,9,17-Trihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione |
| GinkgolideJ |
| (1R,3R,6R,7S,8S,9R,10S,11S,13S,16S,17R)-8-tert-Butyl-6,9,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione |
| Ginkgolid J |
| 7beta-hydroxyginkgolide a |
