Introduction：Basic information about CAS 467-55-0|Hecogenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hecogenin |
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| CAS Number | 467-55-0 | Molecular Weight | 430.620 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 548.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C27H42O4 | Melting Point | 268°C |
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| MSDS | / | Flash Point | 177.8±23.6 °C |
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Names
| Name | Hecogenin |
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| Synonym | More Synonyms |
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Hecogenin BiologicalActivity
| Description | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
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| Target | Human UDP-glucuronosyltransferases[1] |
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| In Vivo | Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. Animal Model: Male Swiss mice (20-30 g) with ethanol[1] Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration: Oral administration; for 15 hours Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa. |
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| References | [1]. Santos Cerqueira G, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012 May 15;683(1-3):260-9. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 548.9±50.0 °C at 760 mmHg |
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| Melting Point | 268°C |
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| Molecular Formula | C27H42O4 |
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| Molecular Weight | 430.620 |
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| Flash Point | 177.8±23.6 °C |
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| Exact Mass | 430.308319 |
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| PSA | 55.76000 |
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| LogP | 4.22 |
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| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
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| Index of Refraction | 1.559 |
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| InChIKey | QOLRLLFJMZLYQJ-LOBDNJQFSA-N |
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| SMILES | CC1CCC2(OC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CC(=O)C3(C)C1C2C |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36 |
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| WGK Germany | 3 |
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Synonyms
| 5ALPHA-SPIROSTAN-3BETA-OL-12-ONE |
| 5α-Spirostan-12-one, 3β-hydroxy-, (25R)- |
| (25R)-5-Spirostan-3-ol-12-one |
| MFCD00067285 |
| (22R,25R)-3β-Hydroxy-5α-spirostan-12-one |
| Spirostan-12-one, 3-hydroxy-, (3β,5α,25R)- |
| 12-Oxotigogenin |
| (3β,5α,25R)-3-Hydroxyspirostan-12-one |
| Hocogenin |
| Hecoginin |
| (25R)-3b-Hydroxy-5a-spirostan-12-one |
| Hecogenin |
| EINECS 207-392-4 |
| 3-b-Hydroxy-5-a-spirostan-12-one |
| (3,5,25R)-3-Hydroxysiprostan-1 |
| (3,5,25R)-3-Hydroxysiprostan-12-one |
| (3b,5a,25R)-3-Hydroxyspirostan-12-one |
