CAS 302-23-8|Hydroxyprogesterone acetate

Introduction：Basic information about CAS 302-23-8|Hydroxyprogesterone acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Hydroxyprogesterone acetate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Hydroxyprogesterone acetate
CAS Number	302-23-8	Molecular Weight	372.498
Density	1.1±0.1 g/cm3	Boiling Point	494.3±45.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₂O₄	Melting Point	249-250ºC
MSDS	/	Flash Point	213.5±28.8 °C
Symbol	GHS08	Signal Word	Warning

Names

Name	Progesterone Acetate
Synonym	More Synonyms

Hydroxyprogesterone acetate BiologicalActivity

Description	17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface[1][2].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>Others >>Others
In Vitro	17α-Hydroxyprogesterone (Delalutin) is not androgenic, and that it, like progesterone and certain other sex steroids, does not alter the development of nonreproductive organs[1].
References	[1]. R E Seegmiller, et al. Evaluation of the teratogenic potential of delalutin (17 alpha-hydroxyprogesterone caproate) in mice. Teratology. 1983 Oct;28(2):201-8. [2]. Amy-Eunice Furcron, et al. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Dec;213(6):846.e1-846.e19.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	494.3±45.0 °C at 760 mmHg
Melting Point	249-250ºC
Molecular Formula	C₂₃H₃₂O₄
Molecular Weight	372.498
Flash Point	213.5±28.8 °C
Exact Mass	372.230072
PSA	60.44000
LogP	3.41
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.541
InChIKey	VTHUYJIXSMGYOQ-KOORYGTMSA-N
SMILES	CC(=O)OC1(C(C)=O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC21C
Storage condition	Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5074000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate

CAS REGISTRY NUMBER :: 302-23-8

LAST UPDATED :: 199206

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C23-H32-O4

MOLECULAR WEIGHT :: 372.55

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1 FOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 72 mg/kg

SEX/DURATION :: male 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 896 mg/kg

SEX/DURATION :: female 32 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80500 ug/kg

SEX/DURATION :: female 23 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 500 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 ug/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

Safety Information

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P280
Hazard Codes	Xn: Harmful;
Risk Phrases	R40
Safety Phrases	22-24/25-45
RIDADR	UN 2811 6
WGK Germany	3
RTECS	TU5074000

Synonyms

17-Acetoxyprogesterone

17α-Acetoxyprogesterone

3,20-Dioxopregn-4-en-17-yl acetate

17a-Hydroxy-progesterone acetate

17ALPHA-ACETOXYPROGESTERONE

Prodox acetate

17α-Hydroxy-4-pregnene-3,20-dione 17-acetate

Chlormadinone acetate impurity G

Pregn-4-ene-3,20-dione, 1-(acetyloxy)-

17-Hydroxypregn-4-ene-3,20-dione acetate

EINECS 206-119-6

17-(Acetyloxy)pregn-4-ene-3,20-dione

Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate

Hydroxyprogesterone acetate

Acetoxyprogesterone

Pregn-4-ene-3,20-dione, 17-(acetyloxy)-

ProgesteroneAcetate

3,20-Dioxopregn-4-en-1-yl acetate

17-Hydroxyprogesterone 17α-acetate

4-Pregnen-17α-ol-3,20-dione acetate

MFCD00021156

17-Hydroxyprogesterone acetate

Pregn-4-ene-3,20-dione, 17- (acetyloxy)-

17α-Acetoxy-4-pregnene-3,20-dione

17a-Hydroxyprogesterone Acetate

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