CAS 263718-22-5|DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

Introduction：Basic information about CAS 263718-22-5|DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt
CAS Number	263718-22-5	Molecular Weight	1507.75000
Density	/	Boiling Point	/
Molecular Formula	C₇₆H₉₈N₁₆O₁₅S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Malaria Aspartyl Proteinase FRET Substrate I,[DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS]
Synonym	More Synonyms

BiologicalActivity

Description	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS (10 μM) can be used in the plasmepsin assay to mimic the cleavage site present in hemoglobin (kcat: 0.78 /s, Km: 0.10 μM, for P. falciparum plasmepsin; and kcat: 0.69 /s, Km: 0.16 μM, for P. vivaxplasmepsin.
References	[1]. S Jiang, et al. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. Antimicrob Agents Chemother. 2001 Sep;45(9):2577-84.

Chemical & Physical Properties

Molecular Formula	C₇₆H₉₈N₁₆O₁₅S
Molecular Weight	1507.75000
Exact Mass	1506.71000
PSA	475.28000
LogP	10.04630
InChIKey	PNRPVHDIQAKCPJ-LSHDDWBOSA-N
SMILES	CCCCC(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)c1ccc(N=Nc2ccc(N(C)C)cc2)cc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NCCNc1ccc2cccc(S(=O)(=O)O)c2c1

Synonyms

MALARIA ASPARTYL PROTEINASE SUBSTRATE

MALARIA ASPARTYL PROTEINASE FRET SUBSTRATE I

DABCYL-GLU-ARG-NLE-PHE-LEU-SER-PHE-PRO-EDANS

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS trifluoroacetate salt

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